About Me

Here is Honggang Lyu (Hugo, 吕洪港).

I am a Ph.D. Student (Year 1) majoring in Psychiatry and Mental Health at Renmin Hospital, Wuhan University, supervised by Prof. Zhongchun Liu. My recent focus identifying the potential risk factors and objective biomarkers of psychiatric disorders from genetic perspective to optimize individualized medical interventions.

If you are interested in any aspect of me, I would love to chat and collaborate, please email me at - honggang.lv[at]whu[dot]edu[dot]cn

Academic Background

• Sep 2023 - Now: WuHan University (Ph.D. Candidate, Psychiatry and Mental Health)
• Sep 2020 - June 2023: Jining Medical University (M.S., Psychiatry and Mental Health)
• Sep 2015 - June 2020: Binzhou Medical University (M.B. Clinical Medicine)
  

Research Interests

 The rapid emergence of high-quality genome-wide association studies (GWAS) for common psychiatric disorders provide insights into for understanding their biological underpinnings.
 However, mental illness manifests with remarkable clinical heterogeneity, with patients exhibiting diverse early clinical symptoms. For example, adolescent depression often presents with mood dysregulation, academic disengagement, and non-suicidal self-injurious behaviors, while geriatric depression frequently involves somatic complaints.
 Therefore, identifying potential risk factors and objective biomarkers specific to the early clinical profiles of common psychiatric disorders holds significant value for improving diagnosis and treatment of these debilitating conditions.

• Conducting more large-scale genome-wide association studies (GWAS) for early psychiatric clinical symptoms-level. Leveraging large-scale biobanks like UKBiobank, to further elucidate genetic architecture underlying diverse psychiatric clinical symptoms-level profiles.

• Integrating multi-omics data (e.g., Transcriptomics, proteomics, single-cell and bulk RNA-seq) with cutting-edge statistical approaches (e.g., Mendelian Randomization, Isoform-level TWAS, PWAS, and Single-cell disease relevance score (scDRS)) to accelerate the identification of potential risk factors and objective biomarkers for early-stage psychiatric symptoms-level profiles.

• Validating these findings through downstream experimental work and independent clinical cohorts, with a particular focus on the Chinese Han population.